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  • Title: Chemical characterization of a polar portion in the neutral fraction derived from airborne particulate extracts responsible for the embryotoxicity in the chicken embryo.
    Author: Matsumoto H.
    Journal: J Toxicol Environ Health; 1988; 24(4):533-41. PubMed ID: 3411636.
    Abstract:
    Airborne particulate matter was collected with a high-volume air sampler between June 1984 and May 1985 on the rooftop of our institute. The tar material extracted was separated into six fractions by liquid-liquid partition and silica gel column chromatography. These fractions were then tested for their embryotoxicities by a chicken embryo assay. A moderately polar fraction per weight and a fraction containing polycyclic aromatic hydrocarbons (PAHs) had the greatest toxicity for chicken embryos. When the polar fraction was purified by high-pressure liquid chromatography, the purified fraction was 3.7 times more toxic than the original polar fraction. To determine the responsible components for the toxicity, the purified fraction as well as the original fraction was analyzed by capillary gas chromatography and gas chromatography-mass spectrometry. The characterized components were classified into oxygenated PAHs (containing ketones, quinones, and aldehydes), nitrogen-containing PAHs, diphenyl-substituted aliphatic ketones (or diketones), and esters of aliphatic acids.
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