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  • Title: Chitinase in female Onchocerca gibsoni and its inhibition by allosamidin.
    Author: Gooday GW, Brydon LJ, Chappell LH.
    Journal: Mol Biochem Parasitol; 1988 Jun; 29(2-3):223-5. PubMed ID: 3412376.
    Abstract:
    Chitinase activity has been detected in female worms of Onchocerca gibsoni. With 3,4-dinitrophenyl-tetra-N-acetylchitotetraoside as substrate 50% of maximum activity was achieved at about 25 microM substrate, with inhibition above 50 microM substrate. The antibiotic allosamidin very strongly inhibited the chitinase activity, 50% inhibition being achieved by 200 pM allosamidin in the presence of 45 microM substrate.
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