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  • Title: Neurological basis of respiratory complications in achondroplasia.
    Author: Nelson FW, Hecht JT, Horton WA, Butler IJ, Goldie WD, Miner M.
    Journal: Ann Neurol; 1988 Jul; 24(1):89-93. PubMed ID: 3415202.
    Abstract:
    Evaluation of 32 individuals with achondroplasia revealed that 28% had a history of apnea and 22% had respiratory abnormalities on polysomnography. In those patients requiring posterior fossa decompressive surgery, improvement was noted in follow-up polysomnograms. Multimodality studies suggested that brainstem compression was common in achondroplasia and could account in part for the abnormal respiratory function in this disorder, including obstructive apnea, central apnea, and hypoxemia.
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