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  • Title: [Changes in hepatocyte dehydrogenase activity in different zones of liver acini during the revascularization of ischemic extremities].
    Author: Mishnev OD, Shchegolev AI, Raksha AP.
    Journal: Arkh Anat Gistol Embriol; 1988 May; 94(5):64-8. PubMed ID: 3415496.
    Abstract:
    After ischemia (3, 6, 9 and 12 h) of the hind extremities in dogs with a subsequent revascularization for 2 h, enzymatic activity of hepatocytes changes. After ischemia for 3 h the enzymatic activity increases. Restoration of the blood flow at later stages of the experiment results in a progressive decrease of dehydrogenase and diaphorase activities. To a greater extend the changes of the enzymatic activity are observed in perivenular hepatocytes (in the 3d zone of the hepatic acinus).
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