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  • Title: Chemical Constituents from Staminate Flowers of Eucommia ulmoides Oliver and Their Anti-Inflammation Activity in Vitro.
    Author: Li R, Huang T, Nie L, Jia A, Zhang L, Yuan Y, Hong Y, Wang J, Hu X.
    Journal: Chem Biodivers; 2021 Aug; 18(8):e2100331. PubMed ID: 34155779.
    Abstract:
    Three new monoterpenoids, named eucomylides A-C (1-3), along with six known compounds (4-9) were isolated from the staminate flowers of Eucommia ulmoides Oliver. The structures were elucidated by extensive analyses of spectroscopic methods, and their absolute configurations were established by time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. All the compounds along with previously isolated components (10-14) were tested for their anti-inflammatory effects. Two iridoid glycosides (11 and 12) and a flavonoid glycoside (14) showed potent suppressive effects on nitric oxide (NO) production in RAW 264.7 cells, with IC50 values ranging from 17.11 to 22.26 μM.
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