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  • Title: Effects of coronary occlusion on transmural distribution of blood flow in the interventricular septum and left ventricular free wall.
    Author: Ramanathan KB, Wilson JL, Mirvis DM.
    Journal: Basic Res Cardiol; 1988; 83(3):229-37. PubMed ID: 3415633.
    Abstract:
    Collateral flow to the interventricular septum in the dog was measured after septal artery ligation (N = 8) and compared to that in the left ventricular free wall after occlusion of the left anterior descending coronary artery (N = 10) in other animals. Flow was quantitated by radiolabelled microsphere injection before, and 90 s, 2 h and 4 h after occlusion. Perfusion territory size was measured after colored dye infusion; the septal artery bed occupied 21.74 +/- 5.44% of the left ventricle and was significantly smaller than the anterior descending artery zone (40.72 +/- 7.56%). Regional blood flow prior to occlusion was equal in both beds and symmetric across the ventricular wall; endocardial/epicardial and left/right ratios in the anterior descending and septal artery beds were 0.97 +/- 0.14 and 1.14 +/- 0.17, respectively. 90 s after occlusion, left and right septal and endocardial and epicardial anterior descending flows were significantly (p less than 0.05) reduced. Right septal flows exceeded left sided flows to produce a transseptal gradient. However, right septal flow was significantly greater than epicardial anterior bed values, and free wall endocardial/epicardial was significantly lower than septal left/right ratios. By 2 h after occlusion, left and right septal flows were no longer significantly different from preocclusion values, whereas anterior descending flows remained significantly below control for the full 4-h period. Thus, significant differences between the two beds exist, with greater acute collateral flows and more rapid correction of flow deficits in the septum than in the free wall.
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