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  • Title: The disposition of carbohydrate between glycogenesis, lipogenesis and oxidation in liver during the starved-to-fed transition.
    Author: Holness MJ, MacLennan PA, Palmer TN, Sugden MC.
    Journal: Biochem J; 1988 Jun 01; 252(2):325-30. PubMed ID: 3415654.
    Abstract:
    A comparison was made between the time courses of restoration of pyruvate dehydrogenase activities, fructose 2,6-bisphosphate concentrations and lipogenic rates, together with net hepatic glucose flux and glycogen synthesis/deposition in livers of 48 h-starved rats provided with laboratory chow ad libitum for up to 24 h. Increased glycogenesis, lipogenesis and net glucose uptake were observed after 1 h of re-feeding, preceding re-activation of pyruvate dehydrogenase, which occurred after 3-4 h. Increased concentrations of fructose 2,6-bisphosphate were only observed after 5-6 h. The implication of the temporal relationship between these parameters is discussed.
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