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  • Title: Central attenuation of baroreflex precedes the development of hypertension in DOCA-salt-treated rats.
    Author: Takeda K, Nakamura Y, Oguro M, Kawasaki S, Hayashi J, Tanabe S, Nakata T, Lee LC, Sasaki S, Nakagawa M.
    Journal: Am J Hypertens; 1988 Jul; 1(3 Pt 3):23S-25S. PubMed ID: 3415800.
    Abstract:
    To determine whether baroreflex is changed centrally before the development of hypertension in DOCA-salt treated rats, aortic depressor nerve was stimulated electrically 5 days after DOCA-salt treatment in urethane-anesthetized rats: compared with those of sham-operated control rats, blood pressure was not elevated in either awake or anesthetized rats. Aortic depressor nerve (ADN) stimulation elicited frequency-dependent vasodepressor, bradycardiac, and sympatho-inhibitory responses in both DOCA-salt-treated and control rats. However, the responses to ADN stimulation were significantly smaller in DOCA-salt-treated rats. These findings suggest that baroreflex is attenuated centrally before the development of hypertension and this attenuation may contribute to the pathogenesis of DOCA-salt hypertension.
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