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  • Title: [Histamine and lung cancer. II. Human lung cancer cell line and histamine].
    Author: Xue LF, Cheng J, Wang JW, Song Y, Gu SX.
    Journal: Zhonghua Zhong Liu Za Zhi; 1988 Jan; 10(1):19-22. PubMed ID: 3416695.
    Abstract:
    Using tissue culture and biochemical technique, the effects of autacoid-histamine and histamine H-2 receptor's antagonist-cimetidine on human lung cancer cell line were studied. It was shown that histamine at the concentration of 1.8 x 10(-7) M stimulated proliferation of the lung cancer cells, but histamine at the concentration of 1.8 x 10(-4) M or cimetidine at 1.76 x 10(-7) M inhibited growth of the lung cancer cells. Relation between histamine, histidine decarboxylase, histamine formation capacity and tumor proliferation is discussed.
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