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  • Title: Haemodynamic effects of an antihypertensive diuretic substance on the forearm circulation of patients with essential hypertension.
    Author: Bouthier JA, Safar ME, Deschamps E, Tarrade T.
    Journal: Drugs Exp Clin Res; 1988; 14(2-3):221-4. PubMed ID: 3416724.
    Abstract:
    Vascular resistance, arterial compliance and venous tone of the forearm were determined using plethysmographic and Doppler techniques in patients with sustained essential hypertension before and after administration of a new antihypertensive agent with low diuretic effect, cicletanine. After 1 week of treatment, no significant change in the haemodynamic parameters was observed. After 3 months' treatment, blood pressure and forearm vascular resistance significantly decreased, but arterial diameter and forearm venous tone did not change. The study suggested that the antihypertensive effect of cicletanine involved a pharmacological action of the drug on the arterial smooth muscle of both small and large arteries, independently of the blood pressure reduction.
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