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  • Title: Transketolase and 2-oxoglutarate dehydrogenase activities in the brain and liver of the developing rat.
    Author: Iwata H, Tonomura H, Matsuda T.
    Journal: Experientia; 1988 Sep 15; 44(9):780-1. PubMed ID: 3416997.
    Abstract:
    Rat brain transketolase showed little change in activity from birth to adulthood, whereas the liver enzyme activity increased in a biphasic way. In both brain and liver, 2-oxoglutarate dehydrogenase activity increased gradually after birth and reached a plateau at 5 weeks of age. A developmental change in thiamin content in the brain was similar to the change in the 2-oxoglutarate dehydrogenase activity, but this was not the case in the liver.
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