These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Selective antagonism by pirenzepine and N-methyl-scopolamine on muscarinic receptor subtypes of the rat vas deferens.
    Author: Miranda HF, Silva WI, Wolstenholme WW, Cuevas N.
    Journal: Gen Pharmacol; 1988; 19(3):417-20. PubMed ID: 3417103.
    Abstract:
    1. The effects of pirenzepine and N-methyl-scopolamine on the responses to ACh in the isolated rat vas deferens were studied. 2. Pirenzepine was inactive at the M2-ACh receptor. 3. N-methyl-scopolamine was a competitive antagonist (pA2 = 8.76) at M2-ACh receptor, alone or in the presence of pirenzepine. 4. Pirenzepine and N-methyl-scopolamine were both non-competitive antagonists at M1-ACh receptor. 5. The mixture of pirenzepine and N-methyl-scopolamine did not alter the type of antagonism demonstrated by each drug at the M1-ACh receptor.
    [Abstract] [Full Text] [Related] [New Search]