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  • Title: Boholmycin, a new aminoglycoside antibiotic. I. Production, isolation and properties.
    Author: Saitoh K, Tsunakawa M, Tomita K, Miyaki T, Konishi M, Kawaguchi H.
    Journal: J Antibiot (Tokyo); 1988 Jul; 41(7):855-61. PubMed ID: 3417558.
    Abstract:
    A novel aminoglycoside antibiotic, boholmycin, was produced by Streptomyces hygroscopicus H617-25 isolated from a soil sample collected in Bohol Island, the Philippines. It has a pseudotetrasaccharide structure composed of a heptose, two aminosugars and dicarbamoyl-scyllo-inositol. Intrinsic antibacterial activity of boholmycin is weak but it exhibits broad spectrum activity against Gram-positive and Gram-negative bacteria including aminoglycoside-resistant strains. Boholmycin is non-toxic in mice at 1,000 mg/kg intravenously.
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