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  • Title: A Rare Case of Intravenous Metamizole Abuse.
    Author: Nazlı ŞB, Sevindik M.
    Journal: Turk Psikiyatri Derg; 2021; 32(1):70-71. PubMed ID: 34181748.
    Abstract:
    Given the very frequent prescription of non-opiod analgesics (NOA), their dependence potential has been a subject of research. Increased use of NOA in the last decade has led authors to publish case reports to describe the dependence potential of these agents. Metamizole (dipyrone) has become one of the most popular NOA agents, in being easily accessible and inexpensive. Its analgesic effect depends on the central inhibition of cyclo-oxigenase (COX-3) and activation of the opiodergic and cannabinoid systems. Recent research has also stressed its possible anxiolytic effects. Our Literature search indicated no previous reports regarding metamizole misuse. Case of a 41 year old female patient is presented. She had self administered increasing doses of i.v. metamizole reaching up to 10 ampules per day. Considering the risk of mortality due to the metamizole's side effect of agranulocytosis, we thought that it could be a significant contribution to the literature to present a case of a possible metamizole abuse.
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