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  • Title: Priapism and Sickle Cell Disease: Special Considerations in Etiology, Management, and Prevention.
    Author: Ahuja G, Ibecheozor C, Okorie NC, Jain AJ, Coleman PW, Metwalli AR, Tonkin JB.
    Journal: Urology; 2021 Oct; 156():e40-e47. PubMed ID: 34181970.
    Abstract:
    Sickle cell disease (SCD) is an inherited medical condition where sickled red blood cells cause vaso-occlusive crisis. One major complication of SCD is priapism, defined as an erection of the penis lasting over four hours beyond sexual stimulation or orgasm. SCD priapism is caused by sickled erythrocytes obstructing venous outflow and can lead to permanent erectile dysfunction. This article reviews the pathology, physiology, and management of SCD priapism, including potential novel therapeutic agents.
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