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  • Title: Induction of sperm abnormalities in mice by ifosfamide and trofosfamide.
    Author: Quinto I, De Marinis E, De Dominicis G, Della Morte R, Staiano N.
    Journal: Mutat Res; 1988 Sep; 201(1):113-6. PubMed ID: 3419442.
    Abstract:
    The antitumor drugs ifosfamide (IF) and trofosfamide (TF) were evaluated for their capability to induce sperm abnormalities in (C3H X C57BL/6)F1 mice. A statistically significant increase in teratospermia was observed at the 35th day after 5 daily consecutive intraperitoneal injections of the drugs at doses of 25, 50, 100 mg/kg b.w. of TF and 100 mg/kg b.w. of IF. Thus, IF and TF are able to interfere with the differentiation process of spermatogenic cells.
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