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  • Title: IR-Met and IR-Leu enkephalin content in the axolotl brain (Ambystoma mexicanum).
    Author: Asai M, Cano A, Talavera E, Zubieta M.
    Journal: Neuropeptides; 1988 Jul; 12(1):41-2. PubMed ID: 3419559.
    Abstract:
    The peptides met- and leu-enkephalin were identified in the telencephalon, rombencephalon, diencephalon and hypophysis of Ambystoma mexicanum brain by radioimmunoassay procedure. The met-enkephalin was the predominant peptide present in the axolotl brain in contrast with leu-enkephalin, except in the hypophysis where the ratio MET/LEU was 2.2/l. The clear differences in the concentration between enkephalins through a submammalian brain species as Ambystoma genus and the possibility that leu-enkephalin is derived exclusively from a precursor like prodynorphin offers an excellent model for the opioids biosynthetic processes.
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