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  • Title: Early effects of right or left cerebral cortex ablation on mitogen-induced spleen lymphocyte DNA synthesis.
    Author: Barneoud P, Neveu PJ, Vitiello S, Le Moal M.
    Journal: Neurosci Lett; 1988 Aug 01; 90(3):302-7. PubMed ID: 3419641.
    Abstract:
    The cerebral neocortex has been shown to modulate the immune system in an asymmetrical way. In mice, ablation of the left cortex decreases whereas a symmetrical right lesion enhances B and T cell-mediated responses measured at 6-8 weeks after lesioning. In order to study the possibility of neuronal reorganisation during the post-operative period, immunological parameters were determined as early as 2 weeks after right or left cortical ablation. Right lesions depressed lymphocyte DNA synthesis induced by concanavalin A (ConA) and phytohemagglutinin whereas left lesions only depressed ConA-induced blastogenesis. Right or left lesions had no effect on lipopolysaccharide-induced proliferation of B lymphocytes as well as on serum antibody levels. Comparisons between early and late effects of right or left cortical ablation on the immune system showed that each hemicortex differentially modulates lymphocyte subpopulations but also that the neuronal reorganisation following surgery can be different according to the side of cortex lesion.
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