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  • Title: Nickel-Catalyzed, Reductive C(sp3 )-Si Cross-Coupling of α-Cyano Alkyl Electrophiles and Chlorosilanes.
    Author: Zhang L, Oestreich M.
    Journal: Angew Chem Int Ed Engl; 2021 Aug 16; 60(34):18587-18590. PubMed ID: 34213049.
    Abstract:
    A nickel/zinc-catalyzed cross-electrophile coupling of alkyl electrophiles activated by an α-cyano group and chlorosilanes is reported. Elemental zinc is the stoichiometric reductant in this reductive coupling process. By this, a C(sp3 )-Si bond can be formed starting from two electrophilic reactants whereas previous methods rely on the combination of carbon nucleophiles and silicon electrophiles or vice versa.
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