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  • Title: The synthesis and characterization of targeted delivery curcumin using chitosan-magnetite-reduced graphene oxide as nano-carrier.
    Author: Kazemi S, Pourmadadi M, Yazdian F, Ghadami A.
    Journal: Int J Biol Macromol; 2021 Sep 01; 186():554-562. PubMed ID: 34216673.
    Abstract:
    To achieve targeted treatment with fewer adverse effects against fatal cancer diseases, the use of nanoparticles as therapeutic agents or drug carriers has been proved to be very extensive and remarkable, today. In this study, chitosan-magnetite-reduced graphene oxide (CS-Fe3O4-RGO) nanocomposites (NC) were used for the targeted delivery of curcumin (Cur) as anticancer drugs to suppress MCF-7 breast cancer cells and this was accomplished using a facile water-in-oil (W/O) emulsification procedure. FTIR and XRD were used for characterization. The average size distribution of nanoemulsions and their surface charge (zeta potential) were determined by Dynamic light scattering (DLS) analyzer and zeta potential measurement, respectively. SEM Mapping showed the uniform and flat surface for the NC which was confirmed by the EDX diagram. Measurement of VSM exhibited that the Fe3O4-RGOs have superparamagnetic properties. According to the MTT assay, the NC has the highest toxicity at 0.1 against MCF-7 cancer cells. The results of flow cytometry indicated apoptosis in MCF-7 cells. By using the dialysis method, it was determined that curcumin was released faster in an acidic medium. It is expected that the results of this study will be effective in the development of targeted drug delivery as well as the development of CS- Fe3O4-RGO-based drug carriers against various cancer cells during future research.
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