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  • Title: Evidence for two conductance/exchange pathways for chloride in rat parotid secretory granules.
    Author: Goddard MK, Izutsu KT, Johnson DE, Ensign WY, Izutsu SM, Wilkinson LE, Chen SW, Wong JL.
    Journal: Biochem Biophys Res Commun; 1988 Sep 15; 155(2):984-9. PubMed ID: 3421978.
    Abstract:
    Electron probe x-ray microanalysis was used to determine that bromide is localized to rat parotid secretory granules at early stages of an in situ Cl/Br washout experiment. Chloride efflux and bromide influx across the secretory granule membrane occurred with a time order of minutes. Since the Cl washout data indicated minimal Cl binding within the granule, and therefore minimal Br binding, the Br localization results suggest the presence of two or more anion conductance/exchange pathways in the granule membrane for the Cl (Br) ion.
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