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  • Title: Effect of thyroid hormone on the phosphorylation of 110k proteins and the activity of protein kinase NII of rat liver nucleoli.
    Author: Saito T, Suzuki N, Hosoya T.
    Journal: Biochem Int; 1988 May; 16(5):895-901. PubMed ID: 3421987.
    Abstract:
    When rat liver nucleoli were incubated with [gamma-32P] ATP, it was found that 110k proteins were predominantly phosphorylated. The phosphorylation of 110k proteins was decreased by thyroidectomy to about 80% of the normal level and restored 12 h after the injection of triiodothyronine. The activity of nucleolar protein kinase NII which is responsible for phosphorylation of 110k proteins was also increased by about 20-50% after injecting triiodothyronine into thyroidectomized rats. The hormone-stimulated enhancement in the phosphorylation of 110k proteins and protein kinase NII in nucleoli were abolished within 1 h after an injection of cycloheximide, without any change in the amount of the proteins.
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