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  • Title: The genes coding for human pro alpha 1(IV) collagen and pro alpha 2(IV) collagen are both located at the end of the long arm of chromosome 13.
    Author: Boyd CD, Toth-Fejel SE, Gadi IK, Litt M, Condon MR, Kolbe M, Hagen IK, Kurkinen M, Mackenzie JW, Magenis E.
    Journal: Am J Hum Genet; 1988 Feb; 42(2):309-14. PubMed ID: 3422542.
    Abstract:
    We have isolated and characterized a cDNA clone containing DNA sequences coding for the noncollagenous carboxy-terminal domain of human pro alpha 2(IV) collagen. Using this cDNA clone in both Southern blot analysis of DNA isolated from human-mouse somatic-cell hybrids and in situ hybridization of normal human metaphase chromosomes, we have demonstrated that the gene coding for human pro alpha 2(IV) collagen is located at 13q33----34, in the same position on chromosome 13 as the pro alpha 1(IV) collagen gene.
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