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  • Title: The effect of combined treatment of HeLa cells with actinomycin D and radiation upon survival and recovery from radiation damage.
    Author: Ziegler W, Birkenfeld P, Trott KR.
    Journal: Radiother Oncol; 1987 Oct; 10(2):141-8. PubMed ID: 3423303.
    Abstract:
    The presence of actinomycin D during irradiation of HeLa cells leads to radiosensitization under aerobic but not under hypoxic conditions. Depending on the time interval between incubation with the drug and irradiation, pre- or post-treatment with actinomycin D also increases the radiosensitivity of HeLa cells irradiation in air. Pretreatment with actinomycin D does not inhibit recovery from potentially lethal radiation damage. In split-dose experiments, recovery from sublethal radiation damage was not impaired by the drug if present during the entire fractionation interval or if it was given as a short exposure after the first radiation dose.
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