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  • Title: A molecularly imprinted polymer based on MOF and deep eutectic solvent for selective recognition and adsorption of bovine hemoglobin.
    Author: Han S, Yao A, Ding Y, Leng Q, Teng F.
    Journal: Anal Bioanal Chem; 2021 Sep; 413(21):5409-5417. PubMed ID: 34235569.
    Abstract:
    In this study, a novel kind of imprinted polymers based on metal-organic frameworks (MOF@DES-MIPs) was prepared, using bovine hemoglobin (BHb) as template molecules and deep eutectic solvents (DES) as functional monomers for selective recognition and adsorption of BHb. MOF were used as the substrates to improve the accessibility of imprinted sites and DES as the functional monomers to produce different forces for BHb to help the formation of imprinted sites. Imprinted polymer films were taken to provide analyte selectivity. The MOF@DES-MIPs prepared were characterized and evaluated by scanning electron microscope, X-ray diffraction, and Fourier transform infrared spectrometer. We also investigated the influences of BHb concentration and adsorption time on the performance of MOF@DES-MIPs. The maximal adsorption capacity of MOF@DES-MIPs to BHb reached 151.28 mg g-1, and the MOF@DES-MIPs showed good selectivity and fast adsorption equilibrium, which might offer a novel method for the preparation and research of molecularly imprinted polymers of biomacromolecules. In addition, MOF@DES-MIPs were successfully applied in the selective recognition of BHb from a real bovine blood sample. Graphical abstract.
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