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  • Title: Doxycycline effects on the adherence of polymorphonuclear leukocytes to an albumin-coated glass surface.
    Author: Dahlgren C, Norberg B, Eriksson S.
    Journal: Scand J Infect Dis; 1987; 19(5):545-9. PubMed ID: 3423746.
    Abstract:
    The effect of doxycycline on polymorphonuclear leukocyte (PMN) adherence to albumin-coated glass surfaces was studied in the absence and presence of the chemotactic peptide FMLP. Three concentrations of doxycycline were studied, one subtherapeutic (0.1 micrograms/ml), one therapeutic (1.0 micrograms/ml) and one supertherapeutic (10 micrograms/ml). PMN adherence was maximal after incubation for 5 min. FMLP did not affect PMN adherence in the present assay system and at the concentration studied (10(-7)M). PMN adherence remained stable and unaffected in the tested doxycycline concentrations. Thus, the present study could not confirm the reported and challenged doxycycline inhibition of PMN adherence.
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