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Title: Isolation and partial characterization of an antibody enhancing factor from leukaemic owl monkey cell cultures. Author: MacDonald AB, Fraser CE, Rubin AS. Journal: Immunology; 1978 Jan; 34(1):137-47. PubMed ID: 342395. Abstract: Herpesvirus saimiri inoculated into owl monkeys (Aotus trivirgatus) causes leukaemia and lymphoma. Peripheral lymphocytes from leukaemic monkeys grown in culture are predominantly T lymphocytes. The supernatants from these cultures contain a factor which enhances the antibody response of murine B cells to sheep red blood cells (SRBC). The factor has been partially characterized by ammonium sulphate precipitation, DEAE-chromatography, gel filtration over Sephadex G-150 and disc-gel electrophoresis. The enhancing factor is a protein with a molecular weight of approximately 40,000.[Abstract] [Full Text] [Related] [New Search]