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  • Title: Enhancing the tumor cell selectivity of a rhodamine-decorated iridium(III) complex by conjugating with indomethacin for COX-2 targeted photodynamic therapy.
    Author: Liu C, Xiang J, Xiang C, Li H.
    Journal: Bioorg Chem; 2021 Sep; 114():105142. PubMed ID: 34243072.
    Abstract:
    A rhodamine-iridium (III) complex bearing indomethacin moiety, named IM-rho-Ir, was synthesized and evaluated for COX-2 targetable photodynamic therapy. By integrating COX-2 directing group, IM-rho-Ir exhibited enhanced cellular uptake in cancer cells than in normal cells compared to rhodamine-iridium (III) complex without indomethacin moiety.
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