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  • Title: Short-term stimulation of lymphocyte proliferation by indomethacin in vitro and in vivo.
    Author: González-Cabello R, Perl A, Kalmár L, Gergely P.
    Journal: Acta Physiol Hung; 1987; 70(1):25-30. PubMed ID: 3425329.
    Abstract:
    The effect of short-term (up to 24 h) in vitro and in vivo treatment with indomethacin was studied on the blastogenesis of mouse spleen cells. Indomethacin in itself induced a strong proliferation of the lymphocytes starting after 6 h treatment both in vitro and in vivo. Besides, significantly enhanced the blastogenesis of splenocytes in response to various doses of PHA and Con A. The stimulation of lectin-induced lymphocyte proliferation occurred after indomethacin treatment both in vitro and in vivo. Indomethacin had no major effect on the distribution of Lyt-1+ and Lyt-2+ subsets within the spleen cell population. An important role of the prostaglandins in the early phase of lymphocyte activation is suggested.
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