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  • Title: [Olfactory esthesioneuroma. Clinical, histological and therapeutic aspects; apropos of 6 cases].
    Author: Toutée JP, Wassef M, Brette MD, Harbon S, Beauvillain C, Valdazo A, Tran Ba Huy P.
    Journal: Ann Otolaryngol Chir Cervicofac; 1987; 104(6):407-14. PubMed ID: 3426054.
    Abstract:
    On the basis of 6 cases, the authors review the clinical, histological and therapeutic aspects of olfactory esthesioneuromas. These rare tumours, showing varying rates and degrees of progression from one patient to another, generally have a severe prognosis. Diagnosis is based upon precise histological criteria which may be clarified by electromicroscopic data. In difficult cases it may be useful to seek the aid of immuno-histochemical techniques in order to demonstrate the presence in tumour cells of specific neuronal enolase and the labelling of such cells by anti-protein S-100 antibodies. The treatment of choice would appear to be radio-surgical completed by chemotherapy similar to that used in neuroblastomas.
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