These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Morphine suppression of digitalis-induced ventricular arrhythmias.
    Author: Rabkin SW, Einzig S, Benditt DG.
    Journal: Arch Int Pharmacodyn Ther; 1987 Oct; 289(2):267-77. PubMed ID: 3426348.
    Abstract:
    The purpose of the study was to investigate the effect of morphine on digitalis-induced arrhythmias. Seventeen normokalemic dogs [serum potassium 3.9 +/- 0.3 mEg/L (+/- 1 S.D.)] and 19 hypokalemic dogs (serum potassium 2.2 +/- 0.3 mEg/L) were allocated to a morphine pretreatment group (morphine sulfate 3 mg/kg) or to a control group without morphine. Ouabain was administered by a constant infusion of 150 micrograms/kg/hr following an initial bolus of 20 micrograms/kg until animals developed ventricular tachycardia. In hypokalemic dogs, morphine pretreatment significantly (p less than 0.05) increased the digitalis dose required to initiate ventricular tachyarrhythmias (66 +/- 14 vs 37 +/- 11 micrograms ouabain/kg). In normokalemic dogs morphine did not affect the relationship between digitalis dose and arrhythmias. Thus, morphine pretreatment reduces the tendency for hypokalemia to potentiate digitalis-induced ventricular arrhythmias.
    [Abstract] [Full Text] [Related] [New Search]