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  • Title: Treatment of rheumatoid arthritis with L-histidine: a randomized, placebo-controlled, double-blind trial.
    Author: Pinals RS, Harris ED, Burnett JB, Gerber DA.
    Journal: J Rheumatol; 1977; 4(4):414-9. PubMed ID: 342692.
    Abstract:
    A randomized cooperative double-blind trial of oral L-histidine for the treatment of rheumatoid arthritis was carried out. Patients were treated with either L-histidine 4.5 g daily, or placebo, for 30 weeks. None of the clinical measurements showed an advantage of histidine over placebo. A small decrease in rheumatoid factor titer and a small increase in hematocrit were found only in the histidine group. There was suggestive evidence of a beneficial effect of histidine in patients with more active and prolonged disease, based upon subjective doubld-blind evaluations by physicians and patients. No adverse effects of histidine therapy were noted. Histidine cannot be advocated as a therapeutic agent in rheumatoid arthritis, but further studies in certain groups of patients seem justified.
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