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  • Title: Rat and human liver vitamin K epoxide reductase: inhibition by thiol blockers and vitamin K1.
    Author: Wallin R, Patrick SD, Martin LF.
    Journal: Int J Biochem; 1987; 19(11):1063-8. PubMed ID: 3428478.
    Abstract:
    1. Reduction of vitamin K1 2,3-epoxide by rat and human liver vitamin K epoxide reductase is inhibited by N-ethylmaleimide and iodoacetamide. 2. Both enzymes are protected from inhibition by N-ethylmaleimide by vitamin K1 or vitamin K1 2,3-epoxide. 3. Vitamin K1 inhibits reduction of vitamin K1 2,3-epoxide to vitamin K1 which suggests product inhibition of the enzyme.
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