These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Comparison of the effects of 4-methylhistamine on the cell-cycle response between CFU-s and its subpopulation.
    Author: Tang ZC, Xu YH.
    Journal: Int J Cell Cloning; 1987 Nov; 5(6):511-7. PubMed ID: 3429935.
    Abstract:
    When bone marrow cells were treated with an H2-receptor agonist (4-methylhistamine 10(-8) M) before treatment with hydroxyurea (10(-3) M), the suicide rate of spleen colony-forming units (CFU-s) as a whole rose significantly. The rabbit antimouse brain serum (RAMBS)-resistant CFU-s subpopulation was also significantly elevated. Prior treatment of bone marrow cells with cimetidine would prevent this effect of 4-methylhistamine (4-MH). These findings not only confirm that 4-MH can trigger mouse bone marrow CFU-s to enter a DNA synthetic phase of the cell cycle, but also suggest that the RAMBS-resistant CFU-s subpopulation is more sensitive to the effect of 4-MH. Furthermore, this suggests that concentrations of the histamine receptor change during the developmental process of CFU-s.
    [Abstract] [Full Text] [Related] [New Search]