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  • Title: Sclerema neonatorum: a sign of transient hyperammonemia of the newborn.
    Author: Lindenberg JA, Milstein JM, Cox KL.
    Journal: J Pediatr Gastroenterol Nutr; 1987; 6(3):474-6. PubMed ID: 3430253.
    Abstract:
    We cared for four neonates with transient hyperammonemia of the newborn (THAN), all of whom exhibited sclerema during their course. Sclerema is a hardening of the subcutaneous tissues, which gives the tissue a firm, rubber-like quality. This association has not been previously reported, and it may provide a clue to early diagnosis and intervention in THAN.
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