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  • Title: Glucagon-(1-21) fails to inhibit meal size in rats.
    Author: Geary N.
    Journal: Peptides; 1987; 8(5):943-5. PubMed ID: 3432138.
    Abstract:
    Rats were intraperitoneally injected with 115 or 230 nmol/kg pancreatic glucagon or equimolar doses of glucagon-(1-21) just before refeeding at the beginning of the dark phase after a 12 hr period of food deprivation. Glucagon-(1-21) and pancreatic glucagon have been reported to have similar visceral effects, but glucagon-(1-21) does not have pancreatic glucagon's metabolic effects. In this experiment, both doses of pancreatic glucagon, but neither dose of glucagon-(1-21), significantly decreased meal size. This indicates that the C-terminal octapeptide of pancreatic glucagon is necessary for its satiety effect, just as it is for its metabolic effects.
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