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  • Title: Salivary theophylline monitoring in asthmatic children.
    Author: Orłowski L, Paczkowski D, Podleśny J.
    Journal: Pol J Pharmacol Pharm; 1987; 39(2):173-6. PubMed ID: 3432165.
    Abstract:
    The usefulness of determination of salivary concentrations of theophylline for estimation of the serum concentration of the drug was tested in asthmatic children receiving daily 15-20 mg/kg of aminophylline. Theophylline was measured in saliva samples obtained after stimulation with citric acid and bromhexine, and in the blood serum, and the ratio of saliva: serum theophylline concentrations was calculated. The correlation between saliva and serum theophylline concentration was better for saliva samples obtained after bromhexine stimulation (r = 0.9496) than after citric acid stimulation (r = 0.8506). Using the mean value of the saliva: tissue theophylline concentration ratio of 0.6795, the serum theophylline concentration may be satisfactorily predicted (r = 0.9810). The stimulation of salivation with bromhexine is more suitable for the Abbott TDX Drug Monitoring System than the stimulation with citric acid, and the method is suitable for a routine monitoring of theophylline concentrations in the course of theophylline therapy.
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