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  • Title: Comparative structural and functional studies of low molecular weight tropomyosin isoforms, the TPM3 gene products.
    Author: Marchenko MA, Nefedova VV, Yampolskaya DS, Borzova VA, Kleymenov SY, Nabiev SR, Nikitina LV, Matyushenko AM, Levitsky DI.
    Journal: Arch Biochem Biophys; 2021 Oct 15; 710():108999. PubMed ID: 34339666.
    Abstract:
    Tropomyosin (Tpm) is an actin-associated protein and key regulator of actin filament structure and dynamics in muscle and non-muscle cells where it participates in many vital processes. Human non-muscle cells produce many Tpm isoforms; however, little is known yet about their structural and functional properties. In the present work, we have applied various methods to investigate the properties of five low molecular weight Tpm isoforms (Tpm3.1, Tpm3.2, Tpm3.4, Tpm3.5, and Tpm3.7), the products of TPM3 gene, which significantly differ by alternatively spliced internal exon 6 (6a or 6b) and C-terminal exon 9 (9a, 9c or 9d). Our results clearly demonstrate that the properties of these Tpm isoforms are quite different depending on sequence variations in alternatively spliced regions of their molecules. These differences can be important in further studies to explain why these Tpm isoforms play a key role in organization and dynamics of the cytoskeleton.
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