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  • Title: BMAL1 dephosphorylation determines the pace of the circadian clock.
    Author: Schibler U.
    Journal: Genes Dev; 2021 Aug 01; 35(15-16):1076-1078. PubMed ID: 34341001.
    Abstract:
    In mammals, virtually all body cells harbor cell-autonomous and self-sustained circadian oscillators that rely on delayed negative feedback loops in gene expression. Transcriptional activation and repression play a major role in keeping these clocks ticking, but numerous post-translational mechanisms-and particularly the phosphorylation of core clock components by protein kinases-are also critically involved in setting the pace of these timekeepers. In this issue of Genes & Development, Klemz and colleagues (pp. 1161-1174) now show how dephosphorylation of BMAL1 by protein phosphatase 4 (PPP4) participates in the modulation of circadian timing.
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