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  • Title: [A woman with oedema of the lower legs].
    Author: Wolthuis DFGJ, van Bon AC.
    Journal: Ned Tijdschr Geneeskd; 2021 Jun 10; 165():. PubMed ID: 34346645.
    Abstract:
    We present a 46-year-old female with hyperthyroidism, orbitopathy and dermopathy who we diagnosed with Grave's disease. Myxoedema is a rare extrathyroidal symptom and is associated with orbitopathy. TSH-receptor expressing fibroblasts lead to by accumulation of subcutaneous glycosaminoglycans, causing the oedema. Often it is self-limiting, but corticosteroid therapy may be required.
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