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  • Title: Progressive aphasia without dementia: two cases with focal spongiform degeneration.
    Author: Kirshner HS, Tanridag O, Thurman L, Whetsell WO.
    Journal: Ann Neurol; 1987 Oct; 22(4):527-32. PubMed ID: 3435071.
    Abstract:
    Two patients with the syndrome of progressive aphasia without evidence of generalized dementia underwent postmortem neuropathological examinations. In both patients, characteristic changes of Alzheimer's disease, Pick's disease, or Creutzfeldt-Jakob disease were absent. Both patients showed a focal spongiform change involving primarily layer 2 of the left inferior frontal gyrus (and temporal cortex in Patient 1) and a mild astrocytosis in layer 2 and deeper cortical layers. This focal, spongiform cortical degeneration in patients with progressive aphasia does not appear to duplicate any known central nervous system degenerative disease.
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