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  • Title: Genetic heterogeneity in Duchenne dystrophy.
    Author: Hyser CL, Province M, Griggs RC, Mendell JR, Fenichel GM, Brooke MH, Miller JP, Polakowska R, Doherty RA, Quirk S.
    Journal: Ann Neurol; 1987 Oct; 22(4):553-5. PubMed ID: 3435074.
    Abstract:
    We evaluated 173 patients in the Clinical Investigation of Duchenne Dystrophy study to determine if patients from the same kindred were more alike clinically than patients within the study population as a whole. A high intrafamilial correlation was noted for age-adjusted muscle strength scores. While noninherited factors could, in part, explain the results, it seems likely that genetic heterogeneity may contribute to the observed similarity within Duchenne dystrophy kindreds.
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