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  • Title: The role of phosphocreatine and ATP in contraction of normal and ischemic heart.
    Author: Kupriyanov VV, Lakomkin VL, Steinschneider AYa, Novikova NA, Severina MYu, Kapelko VI, Saks VA.
    Journal: Biomed Biochim Acta; 1987; 46(8-9):S493-8. PubMed ID: 3435507.
    Abstract:
    The effect of cellular creatine (Cr) and adenine nucleotides (AdN) deficiency on cardiac work, ATP turnover rate and flux through creatine kinase (CK) has been investigated. Depletion of 60-65% of total heart AdN by 2-deoxyglucose treatment in the presence of pyruvate and subsequent washout resulted in only 25% decrease in contractile activity and phosphocreatine level. Substitution of 80-90% of heart Cr (and PCr) by guanidinopropionic acid (GP) by feeding of rats with 1% GP diet reduced maximal values of cardiac work, ATP turnover and flux through CK by 40-50% and elevated end diastolic pressure and index of diastolic stiffness. Hearts depleted of AdN or glycogen showed better post-ischemic recovery of mechanical function that can be attributed to restriction of accumulation of ischemic catabolytes (lactate, H+, Pi). These data imply that in myocardium PCr is an essential high energy phosphate and contractile function stays unchanged at significantly reduced ATP levels.
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