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  • Title: A possible role for calmodulin in Ca2+-induced swelling of mitochondria.
    Author: Hatase O, Itano T, Matsui H, Doi A, Etoh S, Nishio H, Nakahara S.
    Journal: Biochem Int; 1987 Oct; 15(4):793-9. PubMed ID: 3435542.
    Abstract:
    Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 microM) and low (more than 100 microM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.
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