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  • Title: Postvaccinal encephalomyelitis without cutaneous vaccination reaction.
    Author: Rockoff A, Spigland I, Lorenstein B, Rose AL.
    Journal: Ann Neurol; 1979 Jan; 5(1):99-101. PubMed ID: 34358.
    Abstract:
    A 5-year-old girl developed a progressive febrile neurological illness consisting of right focal seizures, right hemiparesis, and stupor evolving over a period of six weeks. During the month preceding the onset of her illness she had received two apparently unsuccessful smallpox vaccinations without a skin lesion. Elevation of cerebrospinal fluid gamma globulin and findings on brain biopsy were consistent with postinfectious encephalitis, and a simultaneous increase in serum vaccinia antibody titer suggested that the illness was postvaccinial encephalitis. Clinically, the child developed a severe extrapyramidal movement disorder during the acute phase followed by nine months of stuporous unresponsiveness, yet subsequently made a substantial recovery.
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