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  • Title: Lipid peroxidation induced by cyclophosphamide.
    Author: Berrigan MJ, Struck RF, Gurtoo HL.
    Journal: Cancer Biochem Biophys; 1987 Sep; 9(3):265-70. PubMed ID: 3435898.
    Abstract:
    Intraperitoneal administration of a single dose of cyclophosphamide (CP) to rats was found to produce hepatic glutathione depletion and to enhance NADPH-mediated lipid peroxidation in the 15,000 x g supernatant fraction of the liver. These effects were associated with CP in a dose- and a time-dependent manner. The data suggest that the glutathione depletion is, at least in part, responsible for the enhancement in lipid peroxidation induced by CP.
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