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  • Title: Genetic heterogeneity in different BB rat subpopulations.
    Author: Klöting I, Vogt L, Stark O, Fischer U.
    Journal: Diabetes Res; 1987 Nov; 6(3):145-9. PubMed ID: 3436114.
    Abstract:
    Two different BB-rat subpopulations were followed over 7 inbred generations under identical environmental conditions: BB/OK as derived in 1983 from the original stock in Ottawa, BB/PhiK as derived in 1983 from a stock at the University of Pennsylvania, Philadelphia. They showed significant differences in incidence, age at onset, untreated survival time of diabetes, leucopenia and body weight gain. By crossing experiments these phenotypical differences could be attributed to a genetic diversity between the 2 subpopulations. It is concluded that this genetic diversity is based on the heterogeneity of the parental BB Wistar rat stock and that the genetic differentiation between subpopulations of a different history is favoured by the "bottle neck effect", selection, mutation and genetic drift. The study of defined subpopulations and of their genetic interaction will provide deeper insight into the mechanisms of inheritance of diabetes in different species.
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