These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Comparative studies of the antiarrhythmic activity of prolonged action quaternary ammonium derivatives of trimecaine (G-104) and lidocaine (QX-572)].
    Author: Kostin IaV, Fillipov AK, Grenader AK, Gendenshteĭn EI, Porotikov VI.
    Journal: Farmakol Toksikol; 1987; 50(6):45-7. PubMed ID: 3436423.
    Abstract:
    The antiarrhythmic activity of quaternary ammonium derivatives of trimecaine (G-104) and lidocaine (QX-572) was studied on models of arrhythmias induced in dogs by coronary artery occlusion and strophanthin intoxication and in rats by intravenous administration of aconitine. It was found that the antiarrhythmic activity and duration of action of G-104 exceed those of QX-572. The data obtained by the method of electromagnetic flowmetry showed that G-104 in doses of 0.3 and 1 mg/kg produces insignificant changes of hemodynamic parameters. By its action on transmembrane ion currents, G-104 is close to quinidine-like agents.
    [Abstract] [Full Text] [Related] [New Search]