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  • Title: Guillain-Barré syndrome after bortezomib therapy in a child with relapsed acute lymphoblastic leukemia.
    Author: Ceolin V, Cenna R, Resente F, Spadea M, Fagioli F, Bertorello N.
    Journal: Pediatr Hematol Oncol; 2022 Mar; 39(2):187-192. PubMed ID: 34369835.
    Abstract:
    A 12-year-old male being treated for a high-risk relapsed T-acute lymphoblastic leukemia presented progressive weakness and numbness of both legs after having received a chemotherapy regimen that included bortezomib. Diagnosis of acute Guillain-Barré syndrome-like inflammatory demyelinating polyneuropathy was made following clinical examination, cerebrospinal fluid analysis, electrodiagnostic studies, magnetic resonance imaging, and serum immunoglobulin antibodies to anti-ganglioside. Intravenous immunoglobulin treatment was started, resulting in complete clinical recovery. Although in rare cases, Guillain-Barré syndrome after bortezomib therapy has been reported; this paper suggests that GBS may occur when bortezomib is administered and high‑dose intravenous immunoglobulin lead to a resolution of the symptoms.
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