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  • Title: Biomarkers of Exposure and Effect in Nile Tilapia (Oreochromis niloticus) Environmentally Exposed to Multiple Stressors in Egypt.
    Author: Salem HS, Hagras AE, El-Baghdady HAM, El-Naggar AM.
    Journal: Bull Environ Contam Toxicol; 2021 Nov; 107(5):889-894. PubMed ID: 34370087.
    Abstract:
    Chemical pollution poses adverse effects on aquatic organisms, including altered gene expression. This study, therefore, investigated the hepatic expression of biomarkers of exposure and effect in Oreochromis niloticus inhabiting the drainage canal of a sugarbeet factory (an industrially polluted habitat) and the Nile River (a reference habitat). Compared to the Nile River, the drainage canal contained significantly elevated levels of heavy metals (Cd, Fe, Mn, Co, and Pb), nitrate, ammonia, nitrite, chemical oxygen demand, and biological oxygen demand. The liver of O. niloticus from the drainage canal accumulated significantly higher concentrations of the heavy metals. O. niloticus from the drainage canal had significantly higher hepatic expressions of genes related to oxidative stress (GSTa, GPx, and NRF2), metal toxicity (MT), endocrine disruption (Vtg), and hypoxia (HIF1a) and a significantly lower hepatic expression of the apoptosis-associated CAS gene. CYP1A (a detoxification biomarker) expression did not exhibit significant differences. These results provide insights into complex adaptive responses of O. niloticus to multiple chemicals and support the utilization of molecular biomarkers as warning signals for water pollution.
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